My son (20yrs) has been diagnosed w/ UC last fall, he has been on Asacol since. He has noticed his muscle weakened. He had UC symptoms last month again, with the increase dosage of Asacol helped the UC symptoms but he muscles got cramped frequently, join pains, cold/hot feelings, he even couldn't walk or move. We rush him to the local emergency, but the GI Dr's couldn't figure out he had UC issues since there were no typical symptoms. They were keep saying Ascol is safe to take and not too many side effects. But it has paralyzed my son. His muscle pains stopped after he stop taking this drug.